合成磁性N-化碳点作为pH响应的向分子载荷及其抗氧化和抗菌行为的合成
Hayat Alzahrani1, Mohammed S Alkaltham1, Tawfiq Alsulami1
11Department of Food Science & Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh 11451 Saudi Arabia.
Acta pharmaceutica (Zagreb, Croatia)
|July 16, 2025
概括
磁性N-化碳点 (CDs-MNPs) 提供对pH反应的药物递送和强大的抗氧化作用. 这些生物相容纳米材料还显示出显著的抗菌活性,突出显示了它们的治疗潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 碳点 (CD) 是一种新兴的纳米材料,具有多种应用.
- 磁纳米粒子 (MNP) 在有针对性的输送和分离方面具有优势.
- 将这些功能结合起来,可以产生先进的超神智能剂.
研究的目的:
- 为了合成和描述磁性N-化碳点 (CDs-MNPs).
- 评估它们对pH响应药物递送的潜力.
- 为生物医学应用评估它们的抗氧化和抗菌活性.
主要方法:
- 磁性N-化碳点 (CDs-MNPs) 的合成.
- 使用SEM,SQUID,FTIR,XRD,EPR,XPS,BET和TGA进行表征.
- 在不同的pH条件下进行药物释放研究.
- DPPH测定抗氧化活性和MTT测定生物相容性.
- 针对大肠杆菌和金黄色葡萄球菌的抗菌分析.
主要成果:
- 成功合成和表征CDs-MNP,其结构完整性,磁性和热稳定性得到证实.
- 已证明依赖pH值,调节药物释放符合零顺序,希古奇和佩帕斯模型.
- 实现了超过80%的激素清除能力,归因于兴奋剂和功能组.
- 证实了高达100毫克毫升-1的优良生物相容性.
- 呈现出显著的抗菌功效,对格兰氏阴性和格兰氏阳性细菌.
结论:
- CDs-MNP是多功能纳米材料,具有针对药物输送和抗氧化剂治疗的潜力.
- 兴奋剂和磁性特性的协同效应增强了它们的治疗能力.
- 基于CD的纳米杀菌剂在生物医学和食品监测应用中表现有前途.
相关概念视频
Metal-Ligand Bonds
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Polar Covalent Bonds
Covalent bonds are formed between two atoms when both have similar tendencies to attract electrons to themselves (i.e., when both atoms have identical or fairly similar ionization energies and electron affinities). Nonmetal atoms frequently form covalent bonds with other nonmetal atoms. For example, the hydrogen molecule, H2, contains a covalent bond between its two hydrogen atoms. When two separate hydrogen atoms with a particular potential energy approach each other, their valence orbitals...
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism
Nitrous acid is a relatively weak and unstable acid prepared in situ by the reaction of sodium nitrite and cold, dilute hydrochloric acid. In an acidic solution, the nitrous acid undergoes protonation when it loses water to form a nitrosonium ion—an electrophile. Nitrous acid reacts with primary amines to give diazonium salts. The reaction is called diazotization of primary amines.
Extraction: Effects of pH
Consider a neutral form of an amine, B, with a partition coefficient, K, in a liquid mixture containing organic and aqueous phases. The pH of the aqueous phase affects the charge on acidic and basic solutes, and the charged form is usually more soluble in the aqueous phase. Suppose the conjugate acid form of the amine is soluble only in the aqueous phase while the base form is soluble in both phases. Then the distribution coefficient, D, can be given as the ratio of amine concentration in the...
Metabolism of Chemolithotrophs
Chemolithotrophs are microorganisms that obtain energy by oxidizing inorganic molecules such as hydrogen gas (H₂), ammonia (NH₃), reduced sulfur compounds (H₂S, S²⁻), and ferrous iron (Fe²⁺). Unlike heterotrophic organisms that rely on organic carbon, chemolithotrophs transfer electrons from these inorganic donors to the electron transport chain (ETC), generating a proton motive force (PMF) that drives ATP synthesis through oxidative phosphorylation. However, because inorganic electron donors...
Other Unique Bacteria
Magnetic bacteria exhibit a directed movement called magnetotaxis, driven by structures called magnetosomes. These magnetosomes consist of chains of magnetic particles made of either magnetite (Fe₃O₄) or greigite (Fe₃S₄) and are organized in a linear conformation by a protein scaffold within invaginations of the cell membrane. The bacteria align along the north–south magnetic field lines, much like a compass needle. They are typically microaerophilic or anaerobic and are commonly found near the...


