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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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增加脂肪会损害经更年期妇女在血液透析中的血管功能
Juan C Santos1, Mabel Lepera1, Rocío Fernández-Serra2
1Department of Internal Medicine, Faculty of Medicine, Universidad Nacional de Tucumán, San Miguel de Tucumán, Argentina.
概括
增加的体脂肪会对经更年期后患有慢性脏病 (CKD) 的血液透析妇女的血管功能产生负面影响. 体重管理干预措施对于改善这一群体的心血管健康至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
背景情况:
- 慢性病 (CKD) 影响血管健康,特别是在接受血液透析的患者中.
- 患有CKD的绝经后妇女代表心血管并发症的高风险群体.
- 身体脂肪成分在CKD患者血管功能中的作用需要进一步阐明.
研究的目的:
- 在绝经后妇女和血液透析中患有CKD的男性中,研究增加体脂和内皮功能之间的关联.
- 为了比较这些组之间的血管功能参数.
- 探索COVID-19感染对CKD患者内皮功能的影响.
主要方法:
- 横截面研究包括34名经过更年期的女性患有血液透析的CKD (PMW-CKD-HDys) 和31名年龄相匹配的男性患有血液透析的CKD (M-CKD-HDys).
- 评估血压 (SBP,DBP),内皮功能 (流媒扩张 - FMD),体重指数 (BMI),脂肪总指数 (FTI) 和瘦身总指数 (LTI).
- 对COVID-19感染的CKD-HDys患者的一个子组的分析.
主要成果:
- 静脉血压 (SBP) 在男性 (149 ± 2 mmHg) 比女性 (141 ± 3 mmHg) 患有血液透析的CKD更高 (P < 0.05).
- 内皮功能 (EFn) 在两性之间是相似的,但特别在经过血液透析的绝经后妇女中观察到EFn和脂肪总指数 (FTI) 之间的负相关性.
- 在CKD患者中,COVID-19感染与内皮功能进一步恶化有关.
结论:
- 增加的体脂肪会对经期绝经后接受血液透析的CKD妇女的内皮功能产生负面影响,这表明血管风险更大.
- 体重管理策略可能对于改善这种特定患者群体的心血管结果至关重要.
- 需要量身定制的干预措施来增强血管健康并管理慢性病患者的心血管风险,尤其是过度肥胖的绝经后妇女.
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