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Updated: Sep 15, 2025

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针对放射性药物疗法的有效性而最大限度地减少副作用的多尺度计算建模:氨基酸输注的建模

Aryan Golzaryan1, Mohammad Souri1, Farshad M Kashkooli1

  • 1Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran.

PLoS computational biology
|July 16, 2025
PubMed
概括

氨基酸输注 (AAI) 通过增加安全的注射活性和瘤剂量来增强脏向放射性药物治疗 (RPT). 然而,AAI对唾液腺向性RPT的益处有限,突出了危险器官选择的关键作用.

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Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
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Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
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Pharmacokinetic Models: Overview

Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
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Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
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