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通过光和F NMR 检测Nsp3基因段中的SARS-CoV-2 G-四重复合体,使用功能化的核oside模拟物

Sarupa Roy1, Seergazhi G Srivatsan1

  • 1Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune, Dr. Homi Bhabha Road, Pune 411008, India.

Bioconjugate chemistry
|July 16, 2025
PubMed
概括

研究人员开发了一种新型探针来研究SARS-CoV-2 Nsp3.3中的G-四重复 (GQ) 结构. 这种探测器揭示了结构多样性,并有助于开发针对病毒复制的新疗法.

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相关概念视频

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...