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Updated: Sep 15, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Published on: March 15, 2024

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通过调节TFAM介导的线粒细胞衰变和铁稳定,POLR1A抑制铁

Tuo Zhang1, Yanyun Gao2, Marcell Harhai3

  • 1Department of General Thoracic Surgery, Bern University Hospital, Bern, Switzerland; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.

Redox biology
|July 16, 2025
PubMed
概括

癌细胞通过涉及RNA聚合酶I (POLR1A) 和TFAM的新型核-线粒体途径逃避编程细胞死亡 (PCD),抑制铁亡. 抑制这个轴使癌症对铁灭诱导物的敏感.

关键词:
在ATF4中使用ATF4.铁性化 (ferroptosis) 是一种铁的代谢 铁的代谢在Polr1A中使用.在TFAM中,我们可以使用TFAM.线粒细胞衰变 (mitophagy) 是一种神经衰变的过程.

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