喉状细胞癌和以后食道状细胞癌的风险 - 全国基于人口的匹配病例对照研究
相关实验视频
Updated: Sep 15, 2025

03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
533
Peter Elbe1, Isabella Ekheden2, Miroslav Vujasinovic3
1Department of Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden; Division of Surgery, Department of Clinical Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
Cancer epidemiology
|July 16, 2025
概括
患有喉癌的患者每年患食道状细胞癌的风险较低 (0.07%). 这种风险低于巴雷特食道的风险,这表明不需要进行例行胃镜监测.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 喉腔状细胞癌 (PSCC) 与食道状细胞癌 (ESCC) 有关.
- 与巴雷特食道 (BE) 相比,PSCC患者的ESCC风险尚未确定.
- 在PSCC患者中进行ESCC的常规内镜监测是有争议的.
研究的目的:
- 确定诊断为PSCC的患者患ESCC的风险.
- 为了将这种风险与在BE患者中观察到的风险进行比较.
- 评估PSCC患者常规胃镜监测的需要.
主要方法:
- 使用瑞典组织病理学报告 (1980-2016) 的回顾性队列研究.
- 包括1055名没有先前或同时患有癌症的PSCC成年患者.
- 对ESCC和全因死亡率计算的危险比率 (HR),将PSCC患者与匹配的一般人群和兄弟姐妹进行比较.
主要成果:
- 四名 (0.4%) PSCC患者在平均2.5年的随访期间发展出ESCC (HR = 14.3; 95% CI = 1.6-132.3).
- 在PSCC患者中,ESCC的年风险为0.07%.
- 患有PSCC的患者面临全因死亡风险增加7.7倍 (HR=7.7;95%CI=6.8-8.6).
结论:
- 在PSCC患者中,ESCC的风险明显低于巴雷特食道患者.
- 对于患有PSCC的患者,不建议进行ESCC的常规长期内镜监测.
- 喉癌的诊断与整体死亡率的增加有关.
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