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Updated: May 4, 2026

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
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一个产后分子开关驱动了帕瓦胺内部神经元的活动依赖成熟

Monika Moissidis1, Leyla Abbasova1, Martijn Selten1

  • 1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK; Medical Research Council Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK.

Cell
|July 16, 2025
PubMed
概括

神经元活动触发了快速升的帕瓦胺表达 (PV+) 内神经元的成熟. 这一过程由氧体增殖器激活的受体马协活性剂1-α (PGC-1α) 介导,它是内部神经元发育的关键调节剂.

关键词:
有 GABA 的其他类型大脑皮层发展基因表达内部神经成熟时间代谢过程线粒体帕瓦尔胺

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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