她的民族医学通过增强细胞增殖和抗炎症来改善卵巢功能障碍
Hai-Tao Zhang1, Ya-Lan Wei1, Lu Chen1
1Medical Research Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China; Fujian Key Laboratory of Women and Children's Critical Diseases Research, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, 350001, China.
Journal of ethnopharmacology
|July 16, 2025
概括
这项研究研究了传统的She民族医学配方MRCSY1#用于治疗由PCOS和POF引起的女性不孕症. 它发现MRCSY1#有效减少炎症和氧化应激,恢复小鼠的生育能力.
科学领域:
- 生殖医学 生殖医学
- 民族植物学 民族植物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 多囊卵巢综合征 (PCOS) 和过早卵巢衰竭 (POF) 是导致女性不孕的主要原因,其特点是荷尔蒙失衡和无排卵.
- 传统的She民族医学配方MRCSY1#用于生殖障碍,但缺乏机械理解.
研究的目的:
- 阐明MRCSY1#在治疗与卵巢功能障碍相关的不孕症中的药理机制.
- 在PCOS和POF的临床前模型中验证MRCSY1#的疗效.
主要方法:
- 使用UHPLC-Q HF-HRMS的植物化学分析在MRCSY1#中确定了153种生物活性化合物.
- 网络药理学确定了参与MRCSY1#的作用的关键基因和途径.
- 治疗效果被评估在脱水氨激素诱导的PCOS和循环胺诱导的POF小鼠模型中,评估了他的病理学,荷尔蒙水平,氧化应激和生育能力.
主要成果:
- 而MRCSY1#的成分,如原卡特丘酸和诺比素,通过PI3K-Akt/MAPK通路减少了卵巢的氧化应激.
- 该配方改善了PCOS小鼠的频率, litter 大小和荷尔蒙平衡.
- 在POF模型中,MRCSY1#抵消了卵细胞成熟停止,促进了排卵,子宫血管再生和整体生育能力恢复.
结论:
- MRCSY1#通过抑制卵巢炎症,氧化应激和颗粒细胞亡,提供了一种多方面的治疗女性不孕症的方法.
- 这些发现支持开发标准化植物疗法,这些疗法来自传统的民族医学治疗不孕症.
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