怀孕期间血压变化模式和早期儿童神经发育轨迹:一个出生队列研究
Xinyue Li1, Xiuxiu Li2, Zijun Yang1
1Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, PR China.
Journal of affective disorders
|July 16, 2025
概括
怀孕期间母亲的血压 (BP) 变化会影响孩子的神经发育. 母亲的稳定,中度血压与更好的儿童神经发育结果有关,而高降低或低增加的模式带来风险.
科学领域:
- 产科和妇科 产科和妇科
- 儿科神经学 儿科神经学
- 发展生物学 发展生物学
背景情况:
- 怀孕期间母亲血压 (BP) 的波动及其对后代神经发育的影响仍未得到充分研究.
- 了解这些关联对于识别潜在风险和干预措施至关重要.
研究的目的:
- 研究母亲在怀孕期间血压变化模式与2岁以下儿童神经发育轨迹之间的关系.
- 为了确定与最佳或延迟儿童神经发育相关的特定母体血压模式.
主要方法:
- 在深出生队列研究中利用了2084对母婴对的数据.
- 应用了轨迹建模来识别不同的母体BP和儿童神经发育模式.
- 使用后勤和Poisson回归来分析关联,控制混杂因子.
主要成果:
- 确定了三种母体血压模式:"中等稳定"",低增加"和"高下降".
- 与"中等稳定"模式相比,患有"高降低"或"低升高"血压模式的母亲生下的孩子患神经发育缓慢的风险增加.
- 特定领域的分析证实",中等稳定"的孕产妇血压通常与儿童神经发育的改善有关.
结论:
- 在怀孕期间,母亲中度和稳定的血压概况与后代的神经发育结果有关.
- 母亲的血压变化,特别是"高降低"和"低增加"模式,可能会对儿童的神经发育产生负面影响.
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