双极性障碍患者的血清神经纤维聚水平及其对认知功能的影响
Elif Nur Donbaloğlu1, Halil Özcan2, Mehmet Ali Donbaloğlu3
1Erzurum City Hospital, Department of Psychiatry, Erzurum, Türkiye.
Journal of affective disorders
|July 16, 2025
概括
在双相情感障碍 (BD) 中血清神经纤维素水平 (NF-L,NF-M,NF-H) 升高表明神经退行. 较高的NF-M和NF-H与较差的认知功能相关,这表明BD神经退行症的潜在生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 精神病学是一个精神病学.
背景情况:
- 血清神经纤维是双相情感障碍 (BD) 中神经退行症的潜在指标.
- 这项研究研究了神经纤维光 (NF-L),中等 (NF-M) 和重 (NF-H) 链在BD阶段的水平.
研究的目的:
- 为了评估血清NF-L,NF-M和NF-H水平在躁狂,抑郁和BD的euthymic阶段.
- 用中枢神经系统生命体征 (CNSVS) 测试电池探索这些神经丝水平和神经心理功能之间的关系.
主要方法:
- 包括BD患者 (DSM-5诊断) 和健康对照,年龄在18-50岁之间.
- 使用社会人口统计和临床数据形式,临床尺度和CNSVS测试进行评估.
- 通过ELISA对血清NF-L,NF-M和NF-H进行量化.
主要成果:
- 在BD患者和对照人群之间观察到平均NF-L,NF-M和NF-H水平的显著差异 (p < 0.001).
- 在BD患者中,高NF-M和NF-H水平与认知领域负相关,包括NCI,复合记忆,口头/视觉记忆,认知灵活性,执行功能和精神运动速度.
结论:
- 在所有BD阶段中血清神经丝聚的升高表明炎症介导的轴突损伤和BD中神经退行症的潜在生物标志物.
- CNSVS测试电池对于识别BD中神经认知缺陷至关重要.
- 血清NF-M/NF-H与认知表现之间的负相关性突显了它们与神经退行相关的认知衰退的关联.
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