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虫会影响ASD男孩口腔微生物的组成
Si Meng1, Wenyan Huang1, Bo Peng1
1Department of Pediatric Dentistry, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, 510182, China.
Microbial pathogenesis
|July 16, 2025
概括
在患有自闭症谱系障碍 (ASD) 的儿童中,口腔细菌的组成不同,而脏影响了这些变化. 识别与ASD相关的特定口腔微生物对于了解其原因至关重要.
科学领域:
- 微生物学 微生物学
- 神经发育障碍 神经发育障碍
- 口腔健康 口腔健康
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育障碍,可能与口腔微生物有关.
- 牙损是一种常见的牙疾病,会影响口腔微生物的组成,并可能导致ASD研究的混.
研究的目的:
- 为了研究ASD儿童的口腔微生物组成,考虑到空的影响.
- 为了识别与ASD相关的特定口腔微生物,而不是与空相关的变化.
主要方法:
- 一项涉及自闭症儿童和典型发育 (TD) 控制者的病例控制研究,有或没有.
- 16S rRNA高通量测序斑块和唾液样本以分析微生物多样性和组成.
- 将其分为四组:没有的ASD (ASD-N),有的ASD (ASD-C),没有的TD (TD-N) 和有的TD (TD-C).
主要成果:
- 与对照人群相比,患有自闭症儿童的口腔微生物的α多样性较低,β多样性有显著差异.
- 主导的口腔类包括Bacillota和Actinomycetota; 主导的属是Streptococcus和Porphyromonas.
- 像Ruminococcaceae细菌UCG-005,Lactobacillus mucilaginosus和Actinobacillus这样的特定种群在没有虫的ASD儿童中更为丰富,这表明潜在的ASD生物标志物.
结论:
- 虫显著改变了ASD儿童的口腔微生物多样性和组成.
- 甲状腺球菌和杆菌与空和ASD有关.
- 不同的口腔微生物生物标志物可能与空独立于ASD相关,为ASD的口腔病因提供了洞察力.
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