药物特性和注射条件的系统参数分析在雾化喷射流介导的皮肤输送中
Chih-Jung Chen1, Chia-Lang Fang2, Kevin C Weng3
1Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
International journal of pharmaceutics
|July 16, 2025
概括
雾化喷流 (NJS) 传递增强了水友性药物和宏分子的皮肤沉积,提供了快速的药物储存形成和卵泡吸收. 这种无针法显示出安全有效的皮肤病药物输送的潜力.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 无针喷射注射用于皮肤病学,但最佳的药物选择和设备设置需要标准化.
- 雾化喷流 (NJS) 输送是一种有前途的无针方法,可以增强通过皮肤的药物沉积.
研究的目的:
- 评估 nebulized 喷射流 (NJS) 传递的有效性和安全性,用于通过皮肤传递药物.
- 为皮肤病学应用中NJS设备设置和药物选择提供基于证据的建议.
主要方法:
- 试验室透试验 (IVPT) 比较NJS和被动输送用于水友性 (米诺西迪尔) 和脂友性 (利多卡因) 药物,以及宏分子 (德克斯).
- 光和共聚焦显微镜可视化染料透深度和分布.
- 在裸露的小鼠皮肤上进行体内安全性测试,以评估耐受性和潜在的不良影响.
主要成果:
- 与被动递送相比,NJS显著增强了水友性药物 (米诺西迪尔) 和大分子 (德克斯) 的皮肤沉积.
- NJS表现出快速的药物储存 (在30秒内) 和显著的卵泡药物吸收.
- NJS将水友性和脂友性染料输送到表皮和上皮层,随后扩散到更深层.
- 较高的射量和操作压力与较高的氧化物透率相关.
- 在体内,NJS的应用被很好地容忍,观察到轻度的,短暂的红血.
结论:
- 雾化喷射流 (NJS) 输送是一种有效和安全的无针方法,用于增强皮肤间的药物透,特别是对于水友性药物.
- 对于皮肤病学应用,NJS具有显著的潜力,为表皮和上皮提供可靠和可控的药物输送.
- 进一步标准化NJS设备设置和药物选择是广泛临床采用的必要条件.
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