探索慢性肢体威胁性缺血症的最佳止痛策略:一个系统性审查协议
Thanapon Ekkunagul1, Caitlin Sara MacLeod2,3, Jeevan Francis4
1Epidemiology Group, University of Aberdeen Institute of Applied Health Sciences, Aberdeen, Aberdeen, UK thanapon.ekkunagul@abdn.ac.uk.
BMJ open
|July 16, 2025
概括
这一系统性审查将比较慢性四肢威胁性缺血 (CLTI) 的疼痛管理策略. 它评估了各种止痛方法的有效性和安全性,以改善患者的生活质量.
科学领域:
- 血管外科 血管外科
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性肢体威胁性缺血 (CLTI) 导致严重的疼痛,,以及失去肢体的风险.
- 疼痛显著损害患者的生活质量,是复杂的管理.
- 对CLTI患者来说,平衡止痛疗效与不良反应和并发症至关重要.
研究的目的:
- 系统地审查和比较用于CLTI疼痛的药理和局部区域止痛策略.
- 批判性地评估不同疼痛管理方法的有效性和安全性.
- 为优化CLTI疼痛管理提供基于证据的建议.
主要方法:
- 系统审查协议遵循PRISMA指南.
- 搜索了五个电子数据库;包括随机研究,队列研究和案例系列.
- 数据提取和质量评估由至少两名独立审查员进行;主要结果是止痛效果.
主要成果:
- 疼痛缓解在CLTI患者中的有效性.
- 与不同的止痛干预相关的不良影响.
- 疼痛管理对CLTI功能结果的影响.
结论:
- 该审查将综合关于CLTI疼痛管理的证据.
- 调查结果将为临床实践提供有关止痛药选择的信息.
- 本系统性审查旨在改善患有CLTI的患者的治疗结果和生活质量.
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