早期抗生素暴露对学前发展状况的影响:全国性基于人口的研究
Ye Kyung Kim1,2, Peong Gang Park3
1Department of Pediatrics, Konkuk University Medical Center, Seoul, Korea (the Republic of).
BMJ paediatrics open
|July 16, 2025
概括
90天以下的婴儿早期接触抗生素与发育迟缓的适度增加有关,特别是影响运动技能,认知和沟通. 较长的暴露时间与更高的风险相关,需要谨慎的处方做法.
科学领域:
- 儿科神经发育 儿童神经发育
- 药理学和毒理学 药理学和毒理学
背景情况:
- 人们越来越担心早期接触抗生素对神经发育结果的影响.
- 在幼儿时期对这一主题进行的大规模研究是有限的.
研究的目的:
- 调查早期抗生素暴露与学龄前儿童发育迟缓之间的关联.
- 评估在生命的头90天内使用抗生素后,全球和特定领域的发育延迟的风险.
主要方法:
- 一个全国性的,以人口为基础的回顾性队列研究.
- 利用来自韩国国家健康保险系统和NHSPIC (2015-2022) 的数据.
- 包括1,848,841名儿童在4-6个月和54-60个月的年龄被评估.
主要成果:
- 23%的婴儿在生命的前3个月内接受了抗生素.
- 早期接触抗生素显示,发育迟缓风险略有增加 (OR 1.03).
- 总体运动,精细运动,认知和沟通的延迟被发现,观察到剂量-反应关系.
结论:
- 在生命的头90天内接触抗生素可能与全球发育迟缓的适度增加有关.
- 运动技能,认知功能和沟通能力似乎特别受到影响.
- 建议对90天以下的婴儿进行谨慎的抗生素处方.
关键词:
儿童健康 儿童健康相关概念视频
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