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采用细胞疗法的日间时间依赖性

Constant Adriaan Tellinga¹, Roman Friedli¹, Federico Simonetta²

¹Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland.

Trends in cancer

|July 16, 2025

概括

将采用细胞疗法 (ACT),如CAR-T细胞疗法,定时到早期活性阶段,可能会提高癌症治疗的疗效,减少副作用. 这种日间时间的方法利用了身体的自然昼夜节律,以获得更好的结果.

科学领域:

免疫治疗是一种免疫疗法.
时间生物学时间生物学
癌症治疗方法癌症治疗方法

背景情况:

采用细胞疗法 (ACT),包括嵌合抗原受体 (CAR) -T细胞疗法,已经改变了癌症治疗,特别是血液癌症.
患者对ACT的反应存在显著的变化.
新出现的证据表明,ACT的每日时间对治疗结果有影响.

研究的目的:

探索白天时间对ACT疗效和安全的影响.
讨论潜在的潜在机制,包括昼夜时钟的参与.
建议将日间时间策略纳入ACT的临床实践.

主要方法:

在ACT中审查当前关于日间时间影响的研究.
对临床前数据的分析表明,通过早期活性期ACT的管理,瘤控制得到加强,毒性降低.
在癌症环境中考虑新出现的临床数据.

主要成果:

临床前模型显示,当ACT在早期行为活性阶段给予时,瘤控制得到改善,毒性降低.
昼夜时钟机制与这些日间时间效应有关.
临床数据越来越多地支持一天中的时间对癌症治疗结果的影响.

结论:

白天的时间是ACT有效性和安全性的关键因素,但经常被忽视.
通过优化ACT的服用时间来利用昼夜节律,有望提高癌症治疗效果.
将一天中的时间考虑纳入临床方案可能是一个简单但有效的策略,以改善ACT结果.

关键词:

在CART-T中,我们可以使用CAR-T.采用细胞疗法采用细胞疗法慢性治疗是一种慢性疗法.昼夜活动时间 (Circadian)一天中的时间.

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