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在多发性硬化症中高效与非高效疗法的现实世界比较

Sarmad Al-Araji^1,2, Marcello Moccia^1,3, Alessia Bianchi¹

¹Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, UK.

Annals of clinical and translational neurology

|July 16, 2025

概括

高效疗法 (HET) 与非高效疗法 (非HET) 相比,在未接受过治疗的复发性复发性多发性硬化症 (RRMS) 患者中显著降低了疾病活性. 从HET开始,可以在两年内更好地抑制疾病的进展.

科学领域:

神经学神经学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

正在讨论复发性复发性多发性硬化症 (RRMS) 的最佳初始治疗方法,特别是在早期使用高效疗法 (HET) 方面.
了解在未经治疗的RRMS患者中疾病修饰疗法 (DMT) 的治疗结果对于临床决策至关重要.

研究的目的:

为了比较治疗结果,包括没有疾病活性 (NEDA) 的证据,在未经治疗的RRMS患者之间开始HET与非HET.
评估早期HET在抑制RRMS疾病活动中的有效性.

主要方法:

一个观察性前性研究,对两组未经治疗的RRMS患者进行实践研究.
倾向性得分匹配被用来比较接受HET (二甲基 fumarate,fingolimod,glatiramer acetate,natalizumab,ocrelizumab) 和非HET的患者之间的结果.
包括NEDA,复发率,EDSS分数和MRI活动在内的结果在1年和2年后被评估.

主要成果:

在匹配后,分析了448名患者 (110名HET,338名非HET).
在第一年和第二年,HET显著降低了失去NEDA的概率 (HR=0.43和HR=0.61,分别).
与非HET相比,HET的复发率显著降低 (94%在第一年,71%在第二年),EDSS得分降低,MRI活动降低.

结论:

以前没有接受过治疗的RRMS患者从启动高效疗法中受益.
早期使用HET导致在两年内更大程度上抑制疾病活动.

关键词:

高效的疗法高效的疗法多发性硬化症多发性硬化症现实世界的比较.

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