液体分子的结合记忆
Shiyi Qin1, Zhi Yang1, Huimin Liu1
1Institute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, China.
Nature communications
|July 16, 2025
概括
科学家们在液体分子结合动力学中发现了一种普遍的记忆效应,挑战了传统的无记忆假设. 这一通过模拟和显微镜揭示的发现影响了对生物和物质系统的理解.
科学领域:
- 物理科学 物理科学
- 生命科学 生命科学
- 材料科学 材料科学 材料科学
- 生物物理学的生物物理.
背景情况:
- 了解液体分子结合动态对于物理和生命科学至关重要.
- 纳米级的快速动态带来了重大的实验挑战.
- 约束动态通常被认为是无记忆的.
研究的目的:
- 调查和揭示液体分子结合动态中的通用记忆效应.
- 挑战传统假设的无记忆绑定动态.
主要方法:
- 集成大型计算机模拟.
- 缩放理论的应用.
- 实时单粒子跟踪显微镜,具有高时空精度.
主要成果:
- 揭示了液体分子结合动态中的通用记忆效应.
- 使用绑定时间自相关函数量化绑定内存.
- 证明绑定记忆取决于绑定亲和力,环境特性和景观异质性.
结论:
- 结合记忆是液体分子中的普遍现象,而不是无记忆.
- 这种上下文依赖的结合记忆很可能被生物系统用于调节.
- 解密绑定记忆为研究生物系统和软材料提供了新的策略.
相关概念视频
Molecular Comparison of Gases, Liquids, and Solids
43.8K
Particles in a solid are tightly packed together (fixed shape) and often arranged in a regular pattern; in a liquid, they are close together with no regular arrangement (no fixed shape); in a gas, they are far apart with no regular arrangement (no fixed shape). Particles in a solid vibrate about fixed positions (cannot flow) and do not generally move in relation to one another; in a liquid, they move past each other (can flow) but remain in essentially constant contact; in a gas, they move...
43.8K
Cohesion
55.9K
Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature.
On a...
On a...
55.9K
Hydrogen Bonds
10.6K
A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
10.6K
Intermolecular Forces
61.2K
Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
61.2K
Intermolecular Forces and Physical Properties
22.6K
22.6K
Molecular and Ionic Solids
17.6K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
17.6K


