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在人体系统性炎症期间测量线粒体氧化和呼吸 in vivo
Mark A Wefers Bettink1,2, Jelle Zwaag3,4, Bernard Schockaert1
1Department of Anesthesiology laboratory of experimental anesthesiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Scientific reports
|July 16, 2025
概括
在健康的志愿者中,系统性炎症降低了线粒体氧气张力 (mitoPO2),但没有降低氧气消耗 (mitoVO2). COMET系统可以在床边监测线粒体功能,帮助早期诊断疾病.
科学领域:
- 生物医学工程 生物医学工程
- 身体生理学 身体生理学
- 关键护理医学 关键护理医学
背景情况:
- 线粒体功能障碍与各种疾病有关.
- 系统性炎症会影响线粒体呼吸.
- 在体内测量线粒体呼吸是具有挑战性的.
研究的目的:
- 在全身炎症期间评估线粒体氧气张力 (mitoPO2) 和氧气消耗 (mitoVO2).
- 评估床边COMET系统对监测线粒体功能的实用性.
- 为了研究在脂聚糖 (LPS) 给药后线粒体参数的变化.
主要方法:
- 健康的男性志愿者 (n=42) 接受了静脉注射LPS (2 ng/kg).
- 对照组 (n=4) 没有接受LPS.
- 线粒体氧气张力和消耗在基线和1.45h,4h和7h后使用COMET系统进行测量.
主要成果:
- 与对照组相比,在LPS组中,MitoPO2随着时间的推移显著下降 (p=0.002).
- 在LPS后1.45小时观察到最小的线粒PO2 (45.8 ± 1.8 mmHg与75.2 ± 2.6 mmHg相比).
- 米托VO2在不同组之间或随着时间的推移而没有显著变化.
结论:
- COMET监视器在轻度系统性炎症模型中有效检测线粒体参数变化.
- 在床边监测线粒体氧化和呼吸是可行的.
- 这种方法可能有助于早期诊断线粒体功能障碍和ICU患者分层.
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