雌性循环阶段关闭了压力对奖励学习的影响
Morgan P Johnston1, Brandon I Garcia-Castañeda1, Leonor G Cedillo1
1Department of Neuroscience, Developmental and Regenerative Biology, University of Texas at San Antonio, San Antonio, TX, USA.
概括
压力对奖励学习的影响在雌性大鼠中根据雌性周期阶段不同. 不论循环的阶段,反复暴露于压力一般都会增强奖励学习.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 内分泌学 在内分泌学.
背景情况:
- 压力可以改变行为,特别是奖励学习.
- 之前的研究集中在雄性大鼠身上,表明压力增强了奖励学习.
- 雌性老鼠表现出明显的应激反应,需要对它们的奖励学习进行调查.
研究的目的:
- 调查急性和重复的压力如何影响雌性大鼠的奖励学习.
- 确定雌性循环阶段是否影响压力对奖励学习的影响.
- 检查压力对灭绝的影响和新的提示奖励关联学习.
主要方法:
- 雌性老鼠经历了克制压力,在Pavlovian调节之前,给予食物奖励.
- 在条件化过程中,老鼠被按雌性周期阶段分类.
- 在条件化,灭绝和新的提示奖励学习过程中测量了行为反应.
主要成果:
- 一次性压力暴露在非雌性雌性中增强了学习,但在雌性雌性中抑制了学习.
- 在雌性和非雌性雌性中,重复的压力暴露增加了条件反应.
- 之前的压力没有影响灭绝,但在重复暴露后,对新的线索的反应增加了.
结论:
- 奖励学习中的压力诱导的变化是由雌性老鼠的雌性周期阶段调节的.
- 之前的压力史,独立于雌性周期,通常会增强奖励学习和新的暗示关联.
- 这些发现突出了压力,生殖状态和奖励相关行为之间的复杂相互作用.
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