在人体前中枢环中进行语音测序
Jessie R Liu1,2,3, Lingyun Zhao1,2, Patrick W Hullett1,2,4
1Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
这项研究揭示了中部前中心 (mPrCG) 中持续的神经活动对于语音运动测序至关重要. 扰乱这个区域会导致语音失调,突出其在规划和产生复杂的语音声音中的核心作用.
科学领域:
- 神经科学是一个神经科学.
- 语音科学 语言科学
- 发动机控制器的控制器
背景情况:
- 流利的语言依赖于精确的运动规划和语音的序列.
- 语音运动序列的基础的神经机制尚未完全理解.
- 识别涉及的特定大脑区域是理解语音生成的关键.
研究的目的:
- 为了研究语音运动序列的神经基础.
- 识别参与编制和执行序列语音运动计划的大脑区域.
- 探索中间前中心 (mPrCG) 在语音测序中的作用.
主要方法:
- 在14名参与者进行了高密度的直接皮质录音,这些录音是在语音任务中进行的.
- 参与者产生了不同语音和音节序列复杂性的发言.
- 用中部前中心 (mPrCG) 的电皮刺激来评估其功能.
主要成果:
- 在整个语音制作,延迟和目标呈现阶段观察到持续的神经活动.
- 中部前中心 (mPrCG) 的活性与序列复杂性和反应时间相关.
- 对mPrCG的电皮质刺激诱导了类似于言语失语的言语失语.
结论:
- 语音运动测序涉及一个分布式皮质网络.
- 中部前中心 (mPrCG) 在语音运动测序中起着至关重要的作用.
- mPrCG对于准备和执行复杂的语音声音序列至关重要.
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