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Updated: Sep 15, 2025

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

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在RiPP中依赖α-二氧化酶催化宏循环

Yinzheng Xia1, Ying Shi1, Zhixi Xiao1

  • 1State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center of Nanjing University, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Journal of the American Chemical Society
|July 16, 2025
PubMed
概括

这项研究揭示了α-基酸盐依赖的二氧化酶 (αKGDs) 在核糖体合成和转化后修饰的 (RiPPs) 中催化宏循环. 一个由两个成分组成的JMJD系统在兰氏中形成独特的Cys-Tyr交叉链接.

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