从药用植物中提取的无素乙醇提取物的抗菌活性对抗耐甲素的金黄色葡萄球菌
Pouria Nourmohammadi Ghezelghaye1, Mostafa Alibegli2,3, Amirabbas Fazelnejad2,3
1Department of Clinical and Biological Sciences, Faculty of Medicine and Surgery, University of Turin, Turin, Italy.
BMC complementary medicine and therapies
|July 16, 2025
概括
某些药用植物提取物在对抗抗甲素耐药黄金葡萄球菌 (MRSA) 方面表现有前途. 来自Panax人参,Rhus coriaria和Amygdalus communis的无素提取物对MRSA菌株表现出有效性.
科学领域:
- 植物化学 植物化学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 耐美西林黄金葡萄球菌 (MRSA) 感染带来了重大治疗挑战.
- 研究天然抗菌剂对于开发新的治疗策略至关重要.
研究的目的:
- 评估来自各种药用植物的乙醇提取物对MRSA的抗菌疗效.
- 为了确定植物提取物的植物化学特征,包括植物提取物的总含量和素.
主要方法:
- 乙醇提取物是使用化方法制备的.
- 总含量 (TPC) 和总可提取素 (TET) 被量化.
- 最低抑制度 (MICs) 和最小杀菌度 (MBCs) 分别通过微稀释和培养来确定.
主要成果:
- 帕纳克斯人参根表现出最高的TPC (453±22.4毫克GAE/g).
- 狼 (Humulus lupulus) 花的提取产量是最高的 (165.5 ± 21.7 mg GAE/g).
- 在不同提取物中,MICs有所不同,有些提取物对MRSA分离物和ATCC菌株表现出显著活性.
结论:
- 帕纳克斯人参L.,Rhus coriaria L.和Amygdalus communis L.的无素乙醇提取物显示出控制MRSA生长的潜力.
- 结合使用这些提取物,有或没有红色素,可能会增强MRSA抑制.
相关概念视频
01:28Antimicrobial Effectiveness
167
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
167
01:23Antimicrobial Proteins
5.8K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
5.8K