在早产婴儿中与呼吸应急综合征相关的不良周产期结局:回顾性分析
Yu Jie Ma1, Yan Sun2, Cai Hong Zhang3
1Department of Pediatrics, Qilu Hospital of Shandong University (Qingdao), 758 Hefei Road, Qingdao, Shandong, 266035, China.
Italian journal of pediatrics
|July 16, 2025
概括
早产婴儿的呼吸困扰综合征 (RDS) 与母亲的年龄,糖尿病,高血压疾病以及窒息等分娩并发症有关. 诸如产前皮质类固醇和适当的通风等干预措施可以改善结果.
科学领域:
- 新生儿科学 新生儿科学
- 围产儿医学 围产儿医学
- 儿科重症监护 儿科重症监护
背景情况:
- 随着早产率的增加,人们需要了解呼吸系统应急综合征 (RDS) 的并发症.
- RDS显著影响早产婴儿的生存率和长期生活质量.
- 确定围产期风险因素和新生儿结局对于预防和改善预后至关重要.
研究的目的:
- 调查与早产婴儿RDS相关的围产期风险因素.
- 分析RDS的早产婴儿的主要并发症和死亡率.
- 提供关于RDS预防和改善早产新生儿预后的证据.
主要方法:
- 追溯性队列研究,对685名早产婴儿进行了追溯性队列研究,这些婴儿从2018年至2021年被录取到NICU.
- 婴儿分为RDS (n=319) 和非RDS (n=366) 组.
- 对母亲和婴儿特征,围产期因素和新生儿结果的分析.
主要成果:
- 与晚年母亲年龄,剖腹产,妊娠糖尿病和高血压疾病相关的RDS.
- 患有RDS的早产婴儿的妊娠年龄较低,出生体重较轻,出生窒息的发病率更高.
- RDS组显示肺炎,败血症,HIE,BPD,更长时间住院的发病率增加,死亡率为6.0%.
结论:
- RDS与早产婴儿的不良围产和新生儿结局有关.
- 产前皮质类固醇的使用可能会减少窒息的发生率,但会增加超白血症.
- 建议使用标准化通风 (NCPAP而不是机械通风) 和产前皮质类固醇来预防和改善预后.
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