碳水化合物消耗和肝硬化相关的死亡率:一个前性队列研究
Nastaran Raissi-Dehkordi1, Negar Raissi-Dehkordi1, Azita Hekmatdoost2
1Gastroenterology and Liver Disease Research Center, Research Institute for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Science, Tehran, Iran.
BMC research notes
|July 16, 2025
概括
摄入较高的葡萄糖和葡萄糖等糖类与肝硬化患者的死亡风险增加有关. 相反,乳糖摄入显示出一种保护作用,这表明饮食中的碳水化合物类型会影响肝脏疾病的预后.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 慢性疾病管理 慢性疾病管理
背景情况:
- 肝硬化是一种严重的慢性肝病,预后不佳.
- 营养管理对于肝硬化患者至关重要.
- 有限的研究存在于碳水化合物摄入量对肝硬化结果的影响.
研究的目的:
- 研究不同类型的碳水化合物与肝硬化患者的死亡风险之间的关联.
- 澄清饮食碳水化合物在肝硬化预后中的作用.
主要方法:
- 前性队列研究,随访4年.
- 166名新诊断的门诊肝硬化患者.
- 通过168项食物频率问卷评估饮食摄入量.
- 碳水化合物摄入量分析总量,糖,葡萄糖,果糖,糖糖,乳糖和麦芽糖.
- 用于分析的Cox比例危险回归模型.
主要成果:
- 幸存者的卡路里和蛋白质摄入量较高,脂肪和碳水化合物摄入量较低.
- 与较高的糖 (HR=4.9),葡萄糖 (HR=3.4),果糖 (HR=1.6) 和糖 (HR=2.2) 摄入量相关的死亡风险增加.
- 乳糖摄入与死亡率 (HR=0.65) 有负相关性,这表明有潜在的保护作用.
结论:
- 总碳水化合物摄入量,特别是糖 (葡萄糖,果糖,糖糖),与肝硬化病的死亡率有关.
- 乳糖摄入量与死亡率有负面关联,这表明乳糖有保护作用.
- 低于某些碳水化合物的饮食可能会改善肝硬化患者的预后.
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