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Updated: Sep 15, 2025

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

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通过激活CDKN1A-RB-E2F1通路,RC48诱导HER2表达结肠癌细胞的衰老

Jiaxue Wu1, Qianqian Li1, Xiangyu Cheng2

  • 1Shanxi Medical University, Taiyuan, Shanxi, 030001, China.

Current cancer drug targets
|July 17, 2025
PubMed
概括

RC48是一种抗HER2抗体-药物联合体,通过诱导细胞衰老,在结肠癌中显示出抗瘤作用. 这种机制通过增加CDKN1A表达的介导,在HER2-高和HER2-低瘤中有效.

关键词:
这是一种ADC药物.这就是CDKN1A.在HER2中,HER2是HER2.RC48 RC48 RC48 RC48 RC48 RC48 RC48 RC48 RC48 RC48 RC48 RC48 RC48 RC48 RC48 RC48细胞衰老 细胞衰老结肠癌是什么意思结肠癌是什么意思

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