从返回英格兰的旅行者中分离出来的具有BlaPER-7的高度耐药性Vibrio cholerae
Satheesh Nair1, Clare R Barker1,2, Vineet Patel1
1Gastrointestinal Bacteria Reference Unit, UK Health Security Agency, London NW9 5HT, UK.
The Journal of antimicrobial chemotherapy
|July 17, 2025
概括
第七次霍乱大流行表明抗菌素耐药性增加. 研究人员在返回旅行者中发现了blaPER-7和阿兹胺素抗性基因.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 第七次霍乱大流行 (7PET) 具有全球快速传播和抗菌素耐药性增加的特点.
- 多耐药性 (MDR) 霍乱病毒的出现构成了严重的公共卫生威胁.
- 监测V.霍乱的抗菌素耐药性对于有效的公共卫生干预至关重要.
研究的目的:
- 调查布拉佩尔-7的存在,在V. cholerae中对扩展光谱类素产生耐药性,从返回英国的旅行者中分离出来.
- 分析全基因组测序 (WGS) 数据,以检测V. cholerae.中的抗菌素耐药性基因.
主要方法:
- 在2019年至2024年期间收集的161个V. cholerae分离体的全基因组测序 (WGS).
- 对blaPER-7基因和其他抗菌素耐药性基因的WGS数据的选.
- 长读测序来描述抗性基因的遗传背景.
主要成果:
- 在51个V. cholerae O1 ST69分离体中的3个和110个非O1 ST555分离体中的1个中确定了blaPER-7基因.
- 与blaPER-7.一起检测到阿兹罗密辛耐药性 (mph(A)).
- 这两种基因都位于YemVchMDR1元素上,该元素还含有MDR岛,对氨基糖化物,硫胺和花尼醇产生抗性. 这种元素在O1分离物中的等离子体上被发现,并集成到非O1分离物的染色体中.
结论:
- 公共卫生机构在通过被动监测监测耐药性V.霍乱病的监测中发挥着至关重要的作用.
- 监测工作为临床指导,经验治疗策略和旅行建议提供了信息.
- 基因组监测对于了解和控制V. cholerae中抗菌素耐药性的传播至关重要.
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