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相关概念视频

Maximum Size of Aggregate01:12

Maximum Size of Aggregate

238
The maximum size of aggregate is defined as the aperture of the sieve retaining 15 percent or more of the particles present in the aggregate sample. The aggregate's maximum size impacts the concrete's water requirement, workability, and strength. Larger aggregates reduce the surface area needing cement paste coverage, which can lower water needs, thereby allowing a decrease in the water-to-cement ratio when the desired workability and richness of the mix are to be maintained, which can...
238
Aggregates Classification01:29

Aggregates Classification

387
Aggregate classification is generally based on its size, petrographic characteristics, weight, and source. Size classification ranges from coarse to fine aggregates, defined by the size of the particles. Coarse aggregates are particles that do not pass through ASTM sieve No. 4, and aggregates that pass through the sieve are fine aggregates.
Petrographic classification groups aggregates based on common mineralogical characteristics. Some of the common mineral groups found in aggregates are...
387
Unsoundness of Aggregate due to Volume Change01:26

Unsoundness of Aggregate due to Volume Change

181
Unsoundness in aggregates due to volume changes is primarily caused by the physical alterations aggregates undergo, such as freezing and thawing, thermal changes, and wetting and drying. Unsound aggregates, when subjected to these changes, result in volume change upon disintegration. This, in turn, contributes to the deterioration of concrete, including scaling, pop-outs, and cracking. Particular types of aggregates, such as porous flints, cherts, and those containing clay minerals, are...
181

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相关实验视频

Updated: Sep 15, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

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的聚合是tau的聚合.

Indalo Domene-Serrano1,2, Ismael Santa-María2, Felix Hernandez2

  • 1Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.

Histology and histopathology
|July 17, 2025
PubMed
概括
此摘要是机器生成的。

微管相关蛋白 (MAPT) 的聚合驱动病. 具有三或四个结合重复的不同tau异型形成了独特的聚合物,为神经退行性疾病提供治疗点.

更多相关视频

In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening
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In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening

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Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy
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相关实验视频

Last Updated: Sep 15, 2025

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09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

18.5K
In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening
09:49

In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening

Published on: November 20, 2018

18.9K
Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy
12:58

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科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 生物化学 生化学

背景情况:

  • 微管相关蛋白 (MAPT) 存在于不同于微管结合重复的神经元异型中.
  • 这些重复会影响与微管的相互作用及其病态的自我聚合.
  • 陶聚合物是陶病的标志,这是神经退行性疾病的一类.

研究的目的:

  • 为了研究tau自我聚合的机制.
  • 为了确定驱动陶聚合的分子和细胞因素.
  • 分析tau聚合物的结构特征.

主要方法:

  • 检查tau的异形结构.
  • 调查影响陶聚合的因素.
  • 分析tau聚合物的形态.

主要成果:

  • 不同的总体形态由tau异型产生的,其三次与四次的微管结重复.
  • 这些不同的形态与特定的病相关.
  • 了解这些差异是疾病分类的关键.

结论:

  • 的自我聚合机制和驱动因素是复杂的.
  • 异形特异性聚合结构是关键的病理特征.
  • 针对陶聚合物的形成或清除,为陶病症提供了治疗途径.