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Updated: Sep 15, 2025

Author Spotlight: Combining Proximity Ligand Assay with Gamma-H2AX Staining to Characterize Protein Interactions in DNA Damage Response
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对于正确的DNA损伤反应,需要PHRF1的PHD手指对Histone H3 N-终端进行识别

Kanishk Jain1, Pata-Eting Kougnassoukou Tchara2, Abid Khan3

  • 1Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Twin Cities, Minneapolis, MN 55455, United States.

Nucleic acids research
|July 17, 2025
PubMed
概括

植物家庭主体 (PHD) 指蛋白1 (PHRF1) 结合素H3,调节基因表达和DNA损伤反应. 癌症突变破坏了这种相互作用,损害了基因组的完整性.

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