相关实验视频

Updated: Sep 15, 2025

Author Spotlight: Inducing Pseudopregnancy in Female Mice Without the Need for Vasectomized Males Prior to Non-Surgical Embryo Transfer or Artificial Insemination

Author Spotlight: Inducing Pseudopregnancy in Female Mice Without the Need for Vasectomized Males Prior to Non-Surgical Embryo Transfer or Artificial Insemination

Published on: July 7, 2023

冷胚胎转移的科学,是修改自然循环更好吗?

Hassan Hamze¹, Wadad Alameh², Robert Hemmings¹

¹Université de Montréal- Clinique OVO, Montreal, Quebec, Canada.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

|July 17, 2025

概括

与人工周期相比,在修改自然周期 (m-NC) 中的冷胚胎移植导致更高的活产率和更低的流产率. 虽然m-NC需要更多的访问,但它为接受试管婴儿的妇女提供了更好的怀孕结果.

科学领域:

生殖内分泌学生殖内分泌学
在体外受精过程中受精.
产科和妇科产科和妇科

背景情况:

冷胚胎移植 (FET) 是辅助生殖技术的一个关键组成部分.
选择FET的最佳子宫内膜制备方案对于成功的植入和怀孕至关重要.
人工循环 (AC) 和修改自然循环 (m-NC) 是FET的两个常见协议.

研究的目的:

为了比较人工与修改的自然周期中的FET之间的怀孕和产科结果.
评估每个协议所需的访问次数.
评估与FET协议相关的活产率和流产率.

主要方法:

在2022年对1207个FET周期的回顾性研究.
排除40岁以上的患者,有反复的植入失败或反复的怀孕流产.
649个病例的划分包括患者在AC和m-NC组中,根据协议类型,年龄,BMI和AMH.
超声监测m-NC与hCG触发;雌激素和孕激素补充AC.

主要成果:

在AC组中,初始阳性B-hCG较高.
在m-NC组中显著改善临床怀孕和活产率.
与m-NC相比,AC组的流产率显著更高.
两组之间平均子宫内膜厚度没有显著差异.
在m-NC集团中访问次数较多.
在m-NC中,妊娠高血压障碍 (HDP) 的风险较低,但妊娠糖尿病的风险不显著增加.

结论:

在修改后的自然周期中,FET产生了更高的活产率和更低的流产率.
修改后的自然循环需要更频繁的诊所访问.
虽然AC可能会显示出更高的初始阳性妊娠测试,但m-NC似乎对持续的妊娠结果优越,特别是在减少流产率方面.

关键词:

在冷胚胎移植过程中,冷胚胎被移植.人工循环的人工循环改变了自然循环的自然循环.

更多相关视频

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts

Published on: March 2, 2017

Use of Freeze-thawed Embryos for High-efficiency Production of Genetically Modified Mice

Use of Freeze-thawed Embryos for High-efficiency Production of Genetically Modified Mice

Published on: April 2, 2020

相关概念视频

In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

Meiosis II

Meiosis II

Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...