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识别母亲对臭氧暴露和早产之间的关系的敏感窗口

Kang-Kang Zhong¹, Rui Yang¹, Xue-Chun Liu²

¹School of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui Province, China.

International health

|July 17, 2025

概括

母亲暴露于臭氧 (O3) 增加了早产 (PTB) 的风险. 怀孕的中期,从13-27周的怀孕期,被认为是这种风险增加的关键窗口.

科学领域:

环境健康环境健康
生殖流行病学生殖流行病学
围产儿医学围产儿医学

背景情况:

之前对臭氧 (O3) 暴露和早产 (PTB) 的研究已经产生了相互矛盾的结果.
怀孕期间O3暴露的具体时间构成最大风险仍然不清楚.

研究的目的:

进行元分析,评估母体O3暴露与PTB之间的关联.
确定怀孕期间O3暴露的关键窗口与增加PTB风险相关.

主要方法:

对17项通过Embase,PubMed和Web of Science识别的研究进行了元分析.
关于几率比率 (OR) 和95%置信区间 (CI) 的数据使用Stata 15.0.0提取并分析.
进行了异质性,敏感性和出版偏差的测试.

主要成果:

在O3暴露和PTB (OR1.065,95%CI1.056至1.073) 之间发现了显著的正相关性.
中期怀孕 (孕期13至27周) 成为O3暴露的敏感窗口,与此相关的PTB风险增加 (OR1.033,95% CI1.029至1.036).

结论:

怀孕期间母亲的O3暴露与PTB的风险增加独立相关.
怀孕13-27周是O3暴露对PTB构成重大风险的关键时期.
缓解策略,如减少户外活动,使用防护口罩和微量营养素补充,可能有助于减少与O3暴露相关的PTB风险.

关键词:

暴露于O3的时间.这是一个元分析.过早分娩过早分娩是什么易受影响的窗户.

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