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在外部光束辐射疗法 (EBRT) 中使用闪器技术实时剂量测量

Baozhu Lu¹, Yifeng Zhu¹, Brook Byrd¹

¹Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.

Proceedings of SPIE--the International Society for Optical Engineering

|July 17, 2025

概括

这项研究开发了一种基于闪器的系统,用于全皮电子疗法 (TSET) 的实时剂量测量. 闪器在TSET中显示出精确剂量监测的前景,但在临床使用中需要标准化的定位.

科学领域:

医学物理医学物理
辐射瘤学辐射瘤学
皮肤病学皮肤病学

背景情况:

准确的实时剂量测量对于全皮电子疗法 (TSET) 至关重要,以确保有效治疗皮肤T细胞淋巴瘤和其他皮肤恶性瘤.
为了尽量减少对健康组织的毒性,在TSET期间需要精确的剂量输送.
现有的剂量测量方法可能缺乏复杂TSET应用所需的实时精度.

研究的目的:

为TSET开发和实施一个先进的基于闪电器的实时剂量测量系统.
为了提高TSET治疗中的剂量测量精度和可靠性.
评估在TSET中使用闪光灯用于实时剂量监测的可行性.

主要方法:

使用切伦科夫成像摄像机开发基于闪仪的剂量测量系统.
用垂直放置的闪器和二极管参考在5米源至表面距离 (SSD) 的幻影研究.
对体内患者数据的分析,以评估闪器响应的变化,并确定影响因素.

主要成果:

用切伦科夫成像捕获和纠正闪器信号,显示与幻影研究中的二极管测量一致.
在体内患者的数据显示了闪器响应的可变性,受定位和摄像机选择的影响.
该研究证实了闪器是TSET实时剂量测量的可行选择.

结论:

基于闪器的剂量测量是一种可行的实时监测方法,用于全皮电子疗法.
严格标准化闪光灯放置和患者定位对于准确的临床实施至关重要.
需要进一步的研究和标准化,以优化闪器剂量测量,以适用于广泛的TSET应用.

关键词:

切伦科夫的成像成像技术剂量监测和优化剂量的优化实时剂量测量实时剂量测量基于闪器的检测方式.整体皮肤电子疗法 (TSET)

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