基于舞蹈的途径,以推进化疗效应的非药物治疗 (DAANCE):多中心随机对照试验的研究协议
Bhillie Luciani1, Martha Carlson1, Gretchen McNally2
1The Ohio State University Wexner Medical Center.
Research square
|July 17, 2025
概括
适应的阿根廷探戈可以改善乳腺癌幸存者的化疗诱导的神经病变 (CIN) 症状. 这项研究将Tango与标准护理进行比较,评估对感觉和功能的影响. 这些发现可能为CIN缺陷提供一种新的非药物治疗方法.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 康复医学 康复医学 康复医学
背景情况:
- 乳腺癌 (BC) 是常见的,其治疗可以导致化疗诱导的神经病变 (CIN).
- CIN导致感官和功能缺陷,降低幸存者的生活质量,增加跌倒风险.
- 目前用于CIN的治疗方法的疗效和副作用有限,需要采用替代方法.
研究的目的:
- 评估适应的阿根廷坦哥 (坦哥) 作为CIN的非药物干预措施.
- 评估Tango与标准护理 (SOC) 对患者报告的结果和CIN的BC幸存者的功能性措施的影响.
- 探索Tango在管理CIN症状中的潜在作用机制.
主要方法:
- 一个多中心,前性,随机对照试验,将Tango与SOC进行比较.
- 参与者随机分配 (1:1) 给Tango或SOC主动控制.
- 主要结局:从基线到4周测量患者报告的感觉和双重任务功能的结局 (PROs).
主要成果:
- 假设,与SOC相比,4周的坦哥练习会显著改善感觉和功能.
- 二次结局包括疲劳,姿势控制,步态稳定,认知负载和生物标志物在4,8和12周评估.
- 使用线性混合模型进行统计分析,以评估PRO和功能的变化.
结论:
- 坦哥,将体力活动与听觉运动和社会参与相结合,可能提供一种优越的非药物治疗方法来管理CIN.
- 这些发现可能会导致一种安全,有效的干预措施,以改善乳腺癌幸存者的感觉和功能缺陷.
- 本试验 (NCT06749210) 探讨了一种针对癌症治疗常见且令人衰弱的副作用的新疗法策略.
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