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Updated: Sep 15, 2025

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原氧化配对NAD+/NADH动态到瘤休眠和重新激活

Daniela De Martino1, Begoña Zapatería2, Jaclyn B Dunne3

  • 1The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Research square
|July 17, 2025
PubMed
概括

科学家们发现,P4HA2酶通过控制原蛋白生产和线粒体功能来调节瘤细胞休眠状态. 失去P4HA2会触发癌细胞的唤醒,并将ALDH4A1确定为潜在的目标,以防止转移性复发.

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