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Updated: Sep 15, 2025

3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis
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慢性肝病中的ECM1表达:由EGF/STAT1和IFNγ/NRF2信号调节

Yujia Li1, Chenjun Huang1,2, Weiguo Fan3

  • 1Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

JHEP reports : innovation in hepatology
|July 17, 2025
PubMed
概括

皮表皮生长因子 (EGF) /信号转换器和转录1激活器 (STAT1) 信号传输促进细胞外矩阵蛋白1 (ECM1) 表达,防止肝纤维化. 干扰素玛 (IFNγ) /核因子与红色素2相关的因子2 (NRF2) 信号抑制ECM1,加速慢性肝病 (CLD).

关键词:
细胞外矩阵是细胞外矩阵.增长因子增长因子IFNγ IFNγ 的意思是肝脏纤维化 肝脏纤维化在TGF-β的基础上.

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