摄入与非常老的成年人的步行速度有关
Camila Dias Nascimento Rocha1, Gilberto Simeone Henriques2, Karine Aglio Vasconcelos3
1Postgraduate Program in Sciences Applied to Adult Healthcare, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Frontiers in aging
|July 17, 2025
概括
非常老的成年人摄入足够的与更好的步行速度有关,这表明它在肌肉功能和健康衰老中起作用. 保持最佳的水平对于老年人的身体表现至关重要.
科学领域:
- 老年学和营养科学研究
- 肌肉生理学和衰老的过程
- 微量元素的新陈代谢
背景情况:
- 因其抗氧化特性和在肌肉功能和健康衰老中的潜在作用而闻名.
- 对对老年人肌肉健康和体力表现的影响的研究仍然有限.
- 了解的营养状况对于优化老龄化人口的健康结果至关重要.
研究的目的:
- 评估80岁及以上个体的营养状况.
- 调查状态与身体功能关键指标 (包括肌肉力量和质量) 之间的关系.
- 探索摄入量与步行速度等身体表现指标之间的关联.
主要方法:
- 对80岁及以上的功能独立成年人进行了一项横截面观察研究.
- 用电气生物阻抗测量尾骨质量.
- 评估了摄入量,血和红细胞水平,以及对身体表现和手握强度的评估.
- 用Poisson的多变量分析来确定患病率.
主要成果:
- 该研究包括72名参与者,平均年龄为84岁.
- 大多数参与者 (87.5%) 呈现出最佳的血度,没有观察到缺陷;所有人都具有足够的红细胞水平.
- 步行速度与摄入量有显著的关联和相关性,即使对其他因素进行了调整. 增加的消费与低步行速度的流行率降低有关.
结论:
- 这些发现支持这样一个假设,即的抗氧化功能有助于肌肉健康和身体表现非常老.
- 在这个年龄段,恒温机制有效调节循环水平.
- 为老年人群确定特定的参考值,并考虑饮食模式,对于临床实践很重要.
相关概念视频
Drug Dosing: Geriatric Patients
395
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
395
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
861
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
861
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
382
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
382
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
400
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
400
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
354
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
354
Pharmacodynamics in Geriatric Patients: Effects of Age
367
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
367


