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Updated: Sep 15, 2025

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
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Published on: January 31, 2018

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在急性DNA甲基化损伤后,PARP1促进了独立于复制的DNA双链断裂形成

Anne Marie McMahon1,2, Haichao Zhao1, Jia Li1

  • 1Department of Biological Sciences, Klein College of Science, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.

bioRxiv : the preprint server for biology
|July 17, 2025
PubMed
概括

聚-ADP-Ribose聚合酶1 (PARP1) 通过消耗NAD+来调节DNA修复,从而导致独立于复制的双链断裂 (DSB). 这种依赖PARP1的机制影响甲基化损伤后的DNA修复和细胞信号.

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