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Updated: Sep 15, 2025

A Reporter Based Cellular Assay for Monitoring Splicing Efficiency
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无意中介的衰变掩盖了由TDP-43损失引起的神秘拼接事件

Yi Zeng1,2,3, Odilia Sianto1,3, Anastasiia Lovchykova1

  • 1Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.

bioRxiv : the preprint server for biology
|July 17, 2025
PubMed
概括

在前性痴呆和ALS中失去TDP-43会导致神秘拼接. 标准RNA测序错过了这些事件,但抑制无意中介衰变揭示了数百个新的神秘拼接事件.

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