关节动物塔尔苏斯 (tarsus tarsus) 的模式中的发育系统漂移
Benjamin C Klementz1, Sophie M Neu1, Ethan M Laumer1
1University of Wisconsin-Madison, Department of Integrative Biology, Madison 53706, Wisconsin, United States.
bioRxiv : the preprint server for biology
|July 17, 2025
概括
在收割者中,无爪基因对塔尔苏斯发育至关重要,而不是在昆虫中看到的爪子形成. 这一发现揭示了关节动物腿部模式和进化中的显著差异.
科学领域:
- 发展生物学 发展生物学
- 进化生物学 进化生物学
- 遗传学 是一个遗传学.
背景情况:
- 关节动物的腿部模式在很大程度上是通过昆虫模型来理解的,假设保留了基因调节网络.
- 切利谢拉特表现出明显的附属物模式,但关键基因的功能数据有限.
- 众所周知,homeobox基因无爪 (通常缩写为cll) 指定了昆虫中的爪状前.
研究的目的:
- 为了研究收割者,Phalangium opilio.的无爪基因的功能.
- 为了比较无爪在收割者腿部发育中的作用与它在昆虫中已知的功能.
- 为了推断无爪的祖先功能在切利塞拉和泛类动物中.
主要方法:
- 用RNA干扰 (RNAi) 来降低Phalangium opilio的无爪表达.
- 收割者腿部的发育和模式缺陷在敲击后被分析.
- 无爪的同类被调查在不同的化物种.
主要成果:
- 在收割者中,淘汰clawless破坏了尾细胞的生长和模式,影响了近端尾细胞边界.
- 在无爪敲击后,没有观察到对爪子形成的影响.
- 塔尔索斯的切断与缺陷的塔尔索默形成有关.
- 对没有爪子的同类物种的调查表明,在切利的共同祖先中,塔尔萨尔模式的作用很大.
结论:
- 在昆虫和类动物之间,无爪在腿部模式的功能有所不同.
- 收割者无爪在状体发育中起作用,与其昆虫对应物不同.
- 泛类人足附属体的图案显示出显著的发育系统漂移,保存的基因表现出新的功能.
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