饮食纤维摄入量与维生素E介导的认知功能之间的非线性关联:老年人的横截面研究
Qianyi He1, Lucy An2, Yue Yue1
1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Frontiers in nutrition
|July 17, 2025
概括
适度的食纤维摄入量与老年人更好的认知功能有关,维生素E发挥着关键的调解作用. 这表明,一个特定的摄入水平是对大脑健康最优的.
科学领域:
- 营养科学 营养科学
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 新兴研究表明,食纤维在预防认知能力下降方面具有潜力.
- 精确的剂量反应关系和机制,包括特定营养素的作用,需要进一步阐明.
研究的目的:
- 研究饮食纤维摄入量与老年人认知功能之间的非线性关联.
- 探索维生素E在食纤维和认知之间关系中的调解作用.
主要方法:
- 从2011-2014年国家健康和营养检查调查 (NHANES) 中对2,713名老年人的横截面分析.
- 通过24小时回忆评估食纤维摄入量;使用DSST,AFT和CERAD子测试评估认知功能.
- 用于建模非线性关系和值效应的通用添加剂模型 (GAM) 和两部分线性回归;用于评估维生素E作用的调解分析.
主要成果:
- 在认知功能和食纤维摄入量之间观察到J形关系.
- 认知功能在每天摄入约22-30克纤维时停滞不前.
- 维生素E显著调解了85-87%的食纤维摄入量与认知表现之间的关联 (复合z-scores和DSST).
结论:
- 适度的食纤维摄入与老年人最佳的认知表现有关.
- 维生素E是连接食纤维摄入量与认知功能的途径中的重要调解者.
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