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第一次通过效应NLR和PLR在机械血栓切除术中急性前部循环大血管封闭的关系

Guozhang Lu¹, Peijian Wang¹, Bin Xv²

¹Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, China.

Frontiers in neurology

|July 17, 2025

概括

较高的中性粒细胞-淋巴细胞比率 (NLR) 和血小板-淋巴细胞比率 (PLR) 表明,在急性缺血性中风 (AIS) 机械血栓切除术期间,第一通效 (FPE) 失败的风险更高. 这些炎症标志物可以预测经过血栓切除术的AIS患者的结果.

科学领域:

神经学神经学
血液学血液学血液学
干预心脏病学干预心脏病学

背景情况:

急性缺血性中风 (AIS) 管理通常涉及机械血栓切除术.
第一通效应 (FPE) 是血栓切除术成功的一个关键指标.
反映系统性炎症的生物标志物可能与血栓切除术结果相关.

研究的目的:

为了研究中性粒细胞-淋巴细胞比率 (NLR) 和血小板-淋巴细胞比率 (PLR) 以及在接受机械血栓切除术的AIS患者中的第一通效应 (FPE) 之间的关系.
确定NLR和PLR作为AIS治疗期间FPE的潜在预测因子.

主要方法:

对233名经过机械血栓切除术的AIS患者进行了回顾性分析.
数据收集包括血细胞计数,临床细节和功能结果 (修改的兰金表).
后勤回归和接收器运行特征 (ROC) 曲线分析被用来评估NLR和PLR对FPE的预测值.

主要成果:

与未成功FPE患者相比,成功FPE患者的NLR和PLR显著降低.
无论是NLR还是PLR都独立预测了FPE,调整后的赔率比率表明了他们的预测能力.
在预测FPE时,ROC曲线确定了NLR (4.34) 和PLR (148.03) 的关键值.

结论:

升高的NLR和PLR与AIS机械血栓切除术中FPE失败的可能性更高有关.
在评估血栓切除术失败风险方面,NLR和PLR是有价值的,易于获得的生物标志物.

关键词:

急性前部循环大血管封闭症第一次通过效果.机械血栓切除术是一种机械血栓切除术.中性粒细胞-淋巴细胞比率.血小板-淋巴细胞比率的比率.

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