在患有多发性硬化症的个体中描述扩展语言网络
Alexander S Ratzan1,2, Leila Simani1, Jordan D Dworkin3
1Cognitive Neuroscience Division, Department of Neurology, Columbia University Irving Medical Center, New York, NY.
medRxiv : the preprint server for health sciences
|July 17, 2025
概括
多发性硬化症 (MS) 患者表现出语言能力受损,特别是在语义流方面. 这项研究确定了与MS患者语言功能障碍相关的网络级脑成像标记.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 医疗成像医学成像
背景情况:
- 语言功能障碍是多发性硬化症 (MS) 的常见和早期症状.
- 了解MS中语言缺陷的神经基础对于早期检测和干预至关重要.
研究的目的:
- 开发一个网络层面的语言功能障碍在MS的模型.
- 为了确定神经成像相关的语言障碍在MS患者.
主要方法:
- 获得了54名多发性硬化患者和54名健康对照者的功能和结构性大脑MRI和认知数据.
- 为扩展语言网络 (ELN) 计算的功能连接措施和衍生结构成像指标.
- 利用无监督学习来探索MS组中神经成像特征和语言表现之间的关系.
主要成果:
- 与HC相比,MS患者在语义流性和快速自动命名任务方面表现明显差.
- 在MS群体中,ELN内部连接性增加.
- 由神经成像获得的多模式潜伏组件与MS患者的语言表现有独特的相关性.
结论:
- 网络层面的功能和结构大脑测量可以帮助鉴定MS中的语言功能障碍.
- 这些已识别的特征可能成为MS特定语言缺陷的潜在机制和预测因素.
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