青春期的时间和认知功能:从青少年大脑认知发展 (ABCD) 研究和门德尔随机化研究的见解
medRxiv : the preprint server for health sciences
|July 17, 2025
概括
早期青春期的时间与青少年的认知功能较差有关,影响记忆力和执行能力. 虽然有人提出因果关系,但临床影响似乎很小.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 遗传学 遗传学 是一个
背景情况:
- 早期青春期的时间与神经发育的变化和心理健康问题有关.
- 青春期对认知能力的影响尚不清楚.
- 这项研究调查了青少年青春期时间和认知表现之间的关系.
研究的目的:
- 检查青春期的时间与大量青少年队列中的认知功能之间的关联.
- 通过使用遗传数据,探索青春期时间和执行功能之间的潜在因果关系.
主要方法:
- 利用了青少年大脑和认知发展 (ABCD) 研究的10,174名参与者的数据.
- 在基线和2年和4年的随访中评估了6项任务的认知表现.
- 使用线性混合回归模型和孟德尔随机化与外部基因组广泛协会研究 (GWAS) 数据.
主要成果:
- 早期的青春期时间与两性记忆任务 (图像序列记忆,列表排序工作记忆) 的得分较低相关.
- 在与早期青春期相关的单词列表学习和回忆方面观察到较差的表现.
- 门德尔的随机化表明,初潮时的晚年和更好的执行功能之间存在因果关系.
结论:
- 研究结果支持早期青春期时间和认知能力下降之间的因果关系.
- 观察到的效果大小很小,这表明临床意义有限.
- 进一步的研究可能会澄清青春期发育和认知轨迹之间的细微关系.
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