从环境和多基因风险评分对青少年抑郁症的纵向预测
Eileen Y Xu1, Poppy Z Grimes1, Alex S F Kwong1,2
1Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
medRxiv : the preprint server for health sciences
|July 17, 2025
概括
环境和遗传因素预测青少年抑郁症. 一个使用环境风险的新模型 (depRS),如父母的抑郁,虐待,睡眠和饮食,显示出强有力的抑郁症状预测. 将deprss与多基因风险评分 (PRS) 结合起来,提高了预测终身抑郁症的准确性.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 发展心理学 发展心理学
背景情况:
- 青少年抑郁症带来长期风险,需要改进预测模型.
- 多基因风险评分 (PRS) 解释了遗传风险,但环境因素至关重要,但难以量化.
- 现有的模型在预测因素和通用性上有所不同,突出显示了对综合方法的需求.
研究的目的:
- 开发和验证一个模型 (depRS),利用环境风险因素预测青少年抑郁症症状.
- 在2年的随访期评估dePRS和PRS对终身抑郁症的预测能力.
- 探索环境和遗传风险评分在抑郁症预测中的综合实用性.
主要方法:
- 利用了青少年大脑认知发展研究 (N=7,029) 的数据.
- 从大抑郁症全基因组研究中跨祖先生成的PRS.
- 使用弹性网回归训练dePRS与23个基线环境预测因子通过系统性审查和元分析确定.
主要成果:
- 抑郁症状预测模型 (depRS) 解释了16.9%的总体差异.
- 最重要的预测因素包括父母的抑郁,虐待,睡眠时间和节食.
- 根据DepRS的研究,终身抑郁症的分类比机会更好 (AUC=0.68) 和比单独PRS更高的几率比率 (OR=1.73对1.42).
- 结合deprs和prs最大限度地提高了预测准确度 (AUC=0.70).
结论:
- 环境因素,特别是睡眠和饮食,是青少年抑郁症的重要预测因素.
- 对于识别处于风险中的青少年来说,deprs模型显示出有希望的结果.
- 整合环境和遗传风险得分提供了一个强大的方法来提高抑郁症预测的准确性.
更多相关视频
13:08Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
9.0K
06:52Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills
Published on: September 17, 2019
6.4K
相关概念视频
Human Genetics
732
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
732
Longitudinal Research
12.5K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.5K
Longitudinal Studies
248
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
248
Polygenic Traits
66.6K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
66.6K
Depressive Disorders: Etiology
172
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
172
Gene-Environment Interactions
568
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
568
