局部麻醉剂对多药耐药细菌的抗菌活性 in vitro
Jin Sol Lee1, Jeongeun Moon1, Joo Yong Lee1,2
1Department of Anesthesiology and Pain Medicine, Chungbuk National University Hospital 1 Chungdae-ro, Seowon-gu, Cheongju 28644, South Korea.
American journal of translational research
|July 17, 2025
概括
局部麻醉剂对抗多药耐药性病原体具有抗菌作用. 布皮瓦卡因是最有效的,虽然利多卡因是最有效的.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 局部麻醉剂具有超出疼痛管理的潜在抗菌性质.
- 关于局部麻醉剂对多药耐药 (MDR) 病原体的疗效的数据有限.
研究的目的:
- 评估利多卡因,莱沃布皮瓦卡因和布皮瓦卡因的体外抗菌活性.
- 为了评估它们对具有挑战性的MDR细菌的有效性:多药耐药的Pseudomonas aeruginosa (MRPA),耐卡巴胺的Enterobacterales (CRE) 和多药耐药的Acinetobacter baumannii (MRAB).
主要方法:
- 标准化汁微稀释方法 (CLSI指南) 用于确定最小抑制度 (MIC) 和最小杀菌度 (MBC).
- 对MRPA,CRE和MRAB的临床分离物进行测试.
- 通过MALDI-TOF MS和VITEK II系统确认的身份.
主要成果:
- 布皮瓦卡因表现出最高的抗菌活性 (MRAB的MIC为1.6毫克/毫升,CRE为3.2毫克/毫升).
- 利多卡因表现出有限的活性 (MRPA的MIC为16毫克/毫升),而levobupivacaine则表现出中间作用.
- 最低杀菌度 (MBCs) 始终高于MICs,表明不同的疗效.
结论:
- 局部麻醉剂在体外表现出可测量的抗菌作用,对抗MDR病原体.
- 布皮瓦卡因表现出优越的活性,但受到心脏毒性限制;尽管功效较低,但利多卡因提供了更安全,更实用的替代品.
- 研究结果表明,在易感染的手术中,它们可能具有互补作用,需要仔细的临床考虑.
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