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胰岛素样生长因子2和mRNA结合蛋白3的表达及其在乳腺癌的诊断价值

Chao-Qun Wang¹, Jun-Kang Shao¹, Yan Wang²

¹Department of Pathology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.

Frontiers in oncology

|July 17, 2025

概括

胰岛素样生长因子2mRNA结合蛋白3 (IGF2BP3) 在乳腺癌,特别是三阴性乳腺癌 (TNBC) 中被上调. 这种蛋白质显示出作为识别乳腺癌和TNBC的诊断标记物的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

胰岛素样生长因子2 mRNA结合蛋白3 (IGF2BP3) 在乳腺癌中的临床效用和诊断意义仍未得到充分研究.
了解IGF2BP3的表达模式对于推进乳腺癌诊断和了解其分子亚型至关重要.

研究的目的:

研究IGF2BP3蛋白表达在乳腺癌中的临床应用和诊断价值.
评估IGF2BP3表达与各种临床病理特征之间的相关性,包括三阴性乳腺癌 (TNBC) 等分子亚型.

主要方法:

免疫组织化学 (IHC) 用于评估IGF2BP3蛋白表达在299个乳腺癌组织和60个正常乳腺组织中.
进行了统计分析,包括后勤回归,以确定IGF2BP3表达的预测因子,并评估其诊断准确性.

主要成果:

与正常组织 (0%的阳性) 相比,IGF2BP3在乳腺癌组织中显著上调 (11.4%的阳性).
升高的IGF2BP3水平与较高的瘤级别,ER/PR/HER2负面性,Ki-67指数增加和TNBC亚型相关.
IGF2BP3对乳腺癌具有很高的特异性 (100%),对TNBC (88.2% PPV) 具有显著的诊断潜力.

结论:

在乳腺癌中,IGF2BP3被上调,与攻击性TNBC亚型有着显著的关联.
IGF2BP3在区分乳腺癌与正常组织以及识别TNBC方面表现出有希望的诊断价值.
需要进一步的研究来探索IGF2BP3在乳腺癌患者的预后影响.

关键词:

在 IGF2BP3BP3 中.乳腺癌乳腺癌乳腺癌免疫组织化学免疫组织化学胰岛素样生长因子2 mRNA结合蛋白3 胰岛素样生长因子2 mRNA结合蛋白3 预后预后预后

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