性别肯定激素对白天皮质醇度的影响:一项前性研究
Margot W L Morssinkhof1,2,3,4, David Matthew Doyle1,4, Ysbrand D van der Werf5,6
1Department of Medical Psychology, Amsterdam UMC, Amsterdam, the Netherlands.
Neurobiology of stress
|July 17, 2025
概括
性别确认激素治疗 (GAHT) 没有改变跨性别个体的白天唾液皮质醇节律. 虽然观察到皮质醇倾斜的基线性别差异,但三个月的GAHT在跨男性或转女性群体中没有显著变化.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 跨性别者健康 跨性别者健康
背景情况:
- 下垂体-垂体-上腺 (HPA) 轴调节白天皮质醇节奏,对健康至关重要.
- 性差异存在于白天皮质醇模式中,可能受到性激素的影响.
- 以前的研究指出,在性别确认激素治疗 (GAHT) 时,HPA轴发生变化,但白天唾液皮质醇的影响仍未得到研究.
研究的目的:
- 在GAHT之前调查白天唾液皮质醇节律的性别差异.
- 确定三个月的GAHT对跨性别个体的白天唾液皮质醇水平和斜率的影响.
主要方法:
- 唾液皮质醇在24小时内多个时间点测量在11名跨男性和7名跨女性参与者中.
- 测量是在GAHT前三个月和三个月后进行的.
- 分析了白天皮质醇倾斜率和绝对水平,比较基线组和GAHT后组内的变化.
主要成果:
- 在基线时,与转女性组相比,在转男性组观察到更的白天皮质醇倾斜.
- 在GAHT治疗三个月后,在两组中都没有发现绝对皮质醇水平或白天皮质醇斜率的显著变化.
- 证实了白天皮质醇的基线性别差异,但GAHT没有改变这些模式.
结论:
- 三个月的GAHT并没有显著改变跨性别个体的白天唾液皮质醇节律.
- 潜在的HPA轴和皮质醇结合型球蛋白的恒常适应可能解释了缺乏变化的原因.
- 未来的研究应该探索结合/不结合皮质醇和压力在这些适应中的作用.
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