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Hs-CRP/HDL-C比率作为萨尔科佩尼亚的预测性炎症脂质标志物:来自NHANES 2015-2018年的证据

Xin-Yan Guo¹, Liang-Wen Li²

¹Department of Orthopaedics, Tiantai County Chinese Medicine Hospital, Taizhou, Zhejiang, China.

Frontiers in immunology

|July 17, 2025

概括

高敏感性C反应蛋白/高密度脂蛋白胆固醇 (Hs-CRP/HDL-C) 的比率与增加的肉症风险有关. 这种炎症和脂质标志物可能有助于早期检测肉症.

科学领域:

老年学与公共卫生
生物标志物研究生物标志物研究
营养流行病学营养流行病学

背景情况:

标志着肌肉质量和力量损失的萨尔科佩尼亚,构成了重大的公共卫生挑战.
识别可靠的标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志性标志标志标志标志标志标志标志标志标志标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标标
系统性炎症和脂质新陈代谢之间的相互作用可能会影响肉症的发展.

研究的目的:

为了研究高灵敏度C反应蛋白/高密度脂蛋白胆固醇 (Hs-CRP/HDL-C) 的比率与美国人口中的麻症之间的关联.
为了评估Hs-CRP/HDL-C比率作为一个综合标记物,将炎症和脂质代谢整合起来,以评估肉症的风险.

主要方法:

分析了2015-2018年国家健康和营养检查调查 (NHANES) 4152名参与者的数据.
使用从双能X射线吸收计 (DXA) 获得的骨肌肉指数 (SMI) 来诊断萨科佩尼亚.
多变量逻辑回归和受限制的立方线 (RCS) 来评估Hs-CRP/HDL-C比率四分位数与肉症风险之间的关联,控制共变量.

主要成果:

较高的Hs-CRP/HDL-C比率与较高的肉症风险显著相关,表明剂量反应关系 (趋势p<0.05).
Hs-CRP/HDL-C比率的每一个单位的增加都与萨尔科佩尼亚风险增加6%相关 (OR=1.06). 在最高四分之一的参与者有122%更高的风险.
与单个标志物相比,Hs-CRP/HDL-C比率表现出较强的萨尔科佩尼亚预测性能 (AUC:0.685).

结论:

Hs-CRP/HDL-C比率作为一个实用指标,用于识别具有高风险的萨科佩尼亚个体.
这个比率有效地捕捉了慢性炎症和脂质代谢的综合作用,可能有助于早期检测和预防.
需要进一步的前性研究来验证这些发现和临床实用性.

关键词:

在Hs-CRP/HDL-C比率上尼汉斯 (NHANES) 是一个名人.跨截面研究是跨截面研究.这是一种炎症炎症炎症炎症.脂质新陈代谢脂质新陈代谢

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