在阻塞性睡眠呼吸暂停患者中,分量呼出的氧化 (FeNO) 与认知功能之间的关联
Qilin Zhu1, Lili Huang1, Licheng Zhu1
1Department of Respiratory and Critical Care Medicine, Affiliated Nantong Hospital 3 of Nantong University & Nantong Third People's Hospital, Nantong, Jiangsu, 226000, People's Republic of China.
Nature and science of sleep
|July 17, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 与记忆障碍有关. 在中度至重度OSA患者中,更高的微分呼出氧化 (FeNO) 水平与较差的记忆性能相关,这表明气道炎症会影响认知.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 涉及间歇性缺氧和睡眠碎片化,已知是认知障碍因素.
- 分数呼出的氧化 (FeNO) 是一种非侵入性的气道炎症生物标志物.
研究的目的:
- 研究OSA患者的FeNO水平与记忆表现之间的关联.
- 探索FeNO作为OSA认知功能障碍的潜在指标.
主要方法:
- 102名参与者被分为中度/重度OSA (AHI≥15) 和轻度OSA/打 (AHI<15) 组.
- 使用RCFT,DOT和LMT进行记忆评估. 测量了FeNO的50毫升/秒 (FeNO50) 和200毫升/秒 (FeNO200).
- 统计分析包括t测试,奇平方测试,ANOVA,斯皮尔曼相关性和等级回归.
主要成果:
- 与轻度OSA组相比,中度/重度OSA患者表现出更高的FeNO50和FeNO200,更大的白天嗜睡,以及较差的即时/延迟视觉记忆.
- 较差的记忆性能与呼吸暂停-呼吸暂停指数 (AHI) 和FeNO50.0负相关.
- FeNO50独立地预测了较差的即时召回,而FeNO200没有显著的影响.
结论:
- 中度至重度的OSA与立即和延迟视觉记忆的显著损害有关.
- 升高的FeNO50水平与OSA患者的记忆力下降相关.
- 这些发现支持了阻塞性睡眠呼吸暂停中呼吸道炎症和认知功能障碍之间的联系.
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