肺结核复杂的肺癌的研究进展:叙述性审查
Ze-Jun Zhou1, Hai-Yan Xie1, Luca Bertolaccini2
1Department of Respiratory Medicine, Nanjing Chest Hospital, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Translational lung cancer research
|July 17, 2025
概括
肺结核 (PTB) 和肺癌 (LC) 具有复杂的关系,结核病可能通过慢性炎症诱导LC. 管理同时发生的PTB和LC会带来诊断和治疗方面的挑战.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 肺结核 (PTB) 和肺癌 (LC) 是全球重要的健康问题.
- 在PTB和LC之间存在复杂的相互作用,结核病感染在LC患者中更为普遍.
- 同时感染PTB和LC导致更高的误诊率和更差的预后.
研究的目的:
- 为了澄清肺结核和肺癌之间的复杂关系.
- 审查目前有关PTB和LC之间联系的生物机制的研究.
- 讨论PTB和LC患者的同时治疗策略.
主要方法:
- 使用PubMed/MEDLINE数据库进行了全面的文献搜索.
- 获取了相关文章,包括回顾性队列研究,观察性研究,系统性评论和元分析.
- 搜索涵盖了从数据库创建到2024年出版的研究.
主要成果:
- 结核病感染可以通过诸如慢性炎症,痕形成,DNA损伤和免疫功能障碍等机制促进LC的发展和进展.
- 此外,LC还可以触发结核病的重新激活.
- 目前的文献缺乏对并发性PTB和LC的标准化诊断和治疗方案.
结论:
- 同时存在的PTB和LC的管理需要平衡抗瘤和抗结核疗法.
- 治疗决策应根据患者的身体状况进行个性化.
- 综合性干预策略对于优化患者的治疗结果至关重要.
更多相关视频
10:04Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
18.9K
06:03Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
Published on: January 19, 2019
17.3K
相关概念视频
Pulmonary Tuberculosis III
448
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
448
Pulmonary Tuberculosis I
330
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
330
Pulmonary Tuberculosis V
243
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
243
Pulmonary Tuberculosis II
378
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
378
Pulmonary Tuberculosis IV
207
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
207
Other Pulmonary Disorders
913
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
913
