一个全面的数据集,以了解结直肠癌中的免疫动态
Zahra Mokhtari1, Elham Amjadi2, Hamidreza Bolhasani3
1Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Data in brief
|July 17, 2025
概括
这项研究引入了CRC-ICM数据集,包括136名结直肠癌患者的1756张图像. 该数据集有助于研究瘤微环境中的免疫标记物,以改善癌症预后.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物信息学是一种生物信息学.
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因,基于瘤位置 (右结肠,左结肠,直肠) 的独特特征.
- 瘤微环境 (TME) 和其免疫成分在CRC的发展和进展中发挥着关键作用.
- 目前的预后系统,如TNM分类,在预测CRC患者的临床结果方面存在局限性.
研究的目的:
- 为结直肠癌研究开发和呈现一个全面的组织病理显微镜图像数据集 (CRC-ICM).
- 为了促进对TME中免疫相关标记物的分析,以改善CRC预后.
- 为了将免疫标记物表达与临床病理特征相关联,包括瘤横向性.
主要方法:
- 从136名CRC患者的瘤组织部分获取了1756张基因病理显微镜图像.
- 免疫标记物的免疫组合化学染色:CD3,CD8,CD45RO,PD-1,LAG-3和Tim-3. 这些都是免疫标记物的染色.
- 对瘤的侵入边缘和中心的标记物表达的分析,以及详细的临床病理学数据.
主要成果:
- CRC-ICM数据集提供了一个有价值的资源,包括1756张图像和全面的患者数据.
- 包括详细的患者人口统计信息,瘤解剖特征 (右/左侧) 和组织病理学等级.
- 促进对免疫细胞透和免疫标记物表达的研究,与CRC特征相关.
结论:
- CRC-ICM数据集为研究结直肠癌中的免疫相关标志物提供了一个强大的平台.
- 能够更深入地了解TME在CRC病原和预后中的作用.
- 支持开发新的生物标志物,用于预测结直肠癌的临床结果.
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